糖尿病视网膜病变前期患者视网膜神经纤维层厚度变化分析

Analytical investigation of the changes of nerve fiber layer thickness in preclinical patients with diabetic retinopathy

目的:对比OCT测量正常人与糖尿病患者的视网膜神经纤维层厚度(RNFLT)。方法:收集48例2型糖尿病患者与100名正常人纳入本研究。所有患者以及对照组接受OCT检查测量RNFLT,同时测量糖尿病患者的血糖以及糖化血红蛋白。结果:糖尿病患者与正常人平均RNFLT存在显著统计学差异,视盘上方以及5∶00,11∶00,12∶00位RNFLT存在显著统计学差异。随访6mo,记录糖化血红蛋白(HbA1C)与视盘上方,视盘颞侧,视盘下方RNFLT变化的关系。结论:本研究证实控制血糖可以影响RNFLT,无视网膜病变的糖尿病患者与正常人比较,平均RNFLT以及视盘上方RNFLT有轻微减少。

AIM：To compare the retinal nerve fiber layer thickness （ RNFLT ） obtained by optical coherence tomography （ OCT ） between patients with preclinical diabetic retinopathy （ DR） and healthy subjects. METHODS：Forty-eight type 2 diabetic patients and 100 healthy subjects were included in this study. All participants were evaluated for RNFLT by Stratus OCT.In diabetic patients, levels of blood glucose and glycosylated hemoglobin were examined. RESULTS： The mean RNFLT in diabetic patients and healthy subjects was significantly different.The RNFLT of superior quadrant and 5, 11, 12 o＆#39;clock sectors had statistically significant differences. The relationship between the RNFLT changes of HbA1C with superior, temporal, and inferior area was recorded at 6mo follow-up. CONCLUSION： This study suggests that theglycemic control affects RNFLT.The mean and superior quadrant peripapillary RNFLT are slightly less in diabetic patients without retinopathy than in healthy subjects.