“预处理”策略对Ⅱ型糖尿病患者围术期心肌保护作用的研究进展

Progress of study on preconditionin strategy to cardioprotective in type II diabetes mellitus during perioperative period

糖尿病是心血管疾患的独立危险因素,糖尿病患者发生急性心肌梗死后的病死率明显升高。缺血预处理(IPC)、缺血后处理(IPOST)、远端肢体/组织预处理(RIC)以及麻醉药物预处理(APC)等"预处理"策略,已被证明在非糖尿病患者能够发挥明显的心肌保护作用,近年有研究认为,在Ⅱ型糖尿病患者其心肌保护作用被减弱或者消失。现就"预处理"技术对Ⅱ型糖尿病患者缺血性心肌损害的保护作用及其机制的研究进展予以综述。

Diabetes is an independent risk for cardiovascular disease, and the mortality of the diabetes who have experi- enced the acute myocardial infarction is significantly increased. Preconditioning strategy such as ischemic preconditioning （IPC）, postconditioning （IPOST）, distal limb/tissue preconditioning （RIC） and anesthetic preconditioning （APC） have been demonstrated that it can play a significant myocardial protection in non-diabetic patients. In recent years, some studies showed that in type II diabetes mellitus, the cardioprotective effect is attenuated or disappeared. The aim of this article is to re- view the myocardial protective and its mechanism of type II diabetes mellitus with isehemic myocardial damage on preconditioning strategy.