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泛素结合酶E2T在消化系统肿瘤中的表达 被引量：1

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摘要 目的探讨泛素结合酶E2T(UBE2T)在消化系统肿瘤中的表达及其临床意义。方法应用组织芯片技术结合免疫组织化学方法,检测并分析UBE2T在由37例恶性消化系统肿瘤组织及11例消化系统正常组织制成96个点的组织芯片中的表达情况。结果 UBE2T在消化系统恶性肿瘤的高表达率为86.5%(32/37),明显高于正常组织的9.1%(1/11),差异有统计学意义(P<0.001)。结论 UBE2T在消化系统恶性肿瘤组织中呈高表达,可能与消化系统肿瘤的发生相关。
作者 曹传辉 梁基韵 孙景苑 郭学军 刘莉 吴德华
机构地区 南方医科大学南方医院放疗科 南方医科大学南方医院感染内科肝脏肿瘤中心
出处 《广东医学》 CAS CSCD 北大核心 2014年第5期687-688,共2页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81172056)
关键词 泛素结合酶E2T 消化系统肿瘤 组织芯片 免疫组织化学
分类号 R735 [医药卫生—肿瘤]
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参考文献11

  • 1CHEN A, KI,EIMAN F E, MANLEY J 1,, el al. Autoubiquitina- tion of the BRCAI * BARDI RING uhiquitin ligase[ J ]. J Biol Chem, 2002. 277 ( 24 ) : 22085 - 22092.
  • 2PAGAN() M, TAM S W, THEODORAS A M, et al. Role of the ubiquiiin - proteasome pathway in regulating abundanee >f the eye- lin- dependent kinase inhibitor p27 [ J ]. Science, 1995, 269 ( 5224 ) : 682 - 685.
  • 3ARVAND A, BASTIANS H, WELFORD S M, el al. EWS/FI,II up regulates mE2 - C, a eyelin - selective uhiquitin conjugating enzyme involved in cyelin B destntetion[ J 1. Oneogene, 1998. 17 (16) : 2039 -2045.
  • 4OKAMOTO Y, OZAKI T, MIYAZAKI K, et al. UbcHlO is the cancer - related E2 ubiquitin - eonjugating enzyme [ J ]. Ganeer lies, 2003, 63(14) : 4167 -4173.
  • 5TAKATA R, KATAGIRI T, KANEHIRA M, el al. Predicting re- sponse In methotrexate, vinblastine, doxorubiein, and cisplatin neoadjuvant chemotherapy fir bladder cancers through genome - wide gene expressinn pnfiling[ J ]. Clin Caneer Res, 2005, 11 ( 7 ) : 2625 - 2636.
  • 6KIKUCHI , DAIGO Y, KATAGIRI T, et al. Expressinn profiles of non- small eell lung cancers on eDNA microarrays: idenlifiea- tion of genes for prtdietion of lymph - node metastasis and sensiti- vity to anti -cancer drugs [ J]. Oneogene, 2003, 22 ( 14 ) : 2192 - 2205.
  • 7ASHIDA S, NAKAGAWA H, KATAGIRI T, el al. Molecular fea- tures of the transi|ion from prostatie intraepitlelial neoplasia (PIN) to prostate caneer: genome -wide gene -expression profiles of" pros- tare eanee and PINs[J]. Cmleer Res, 2004, 64( 17): 5963 - 5972.
  • 8UEKI T, PARK J H, NISHIDATE T, et al. Ubiquitinalion and downregulation of BRCAI by ubiquilin - conjugating enzyme E2T overexpression in human breast cancer cells [ J]. Caneer Res, 2009, 69 ( 22 ) : 8752 - 8760,.
  • 9KONONEN J, BUBENDORF L, KALLIONIEMI A, et al. Tissue microarrays for high - throughput molecular profiling of tumor spec- imens[Jl. Nat Med, 1998, 4(7): 844-847.
  • 10KELSALI, 1 R, LANGENICK J, MACKAY C, et al. The Faneoni anaemia tomp.nenls UBE2T and FANCM are funcliosally linked to nucleotide excision repair[ J ]. PIxS One, 2012, 7 (5) : e36970.

同被引文献18

  • 1Ding X F, Shen M, Xu L Y, et al. 13, 14-bis (cis-3, 5-dimethyl- 1-piperazinyl) -beta-elemene, a novel β-elemene derivative, shows potent antitumor activities via inhibition of roTOR in human breast cancer cells[J]. Oncol Lett, 2013, 5(5) : 1554.
  • 2Braddford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding[J]. AnalBiochem, 1976, 72: 248.
  • 3Ueki T, Park J H, Nishidate T, et al. Ubiquitination and down- regulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells [J]. Cancer Res, 2009, 69(22): 8752.
  • 4A1-Nedawi K, Meehan B, Kerbel R S, et al. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR [J]. Proc Natl Acad Sci USA, 2009, 106(10): 3794.
  • 5Moheimani F, Roth H M, Cross J, et al. Disruption of t3-Catenin/CBP signaling inhibits human airway epithelial- mesenchymal transition and repair [ J ]. Int J Biochem Cell Biol, 2015, 68: 59.
  • 6Liu Z Q, Zhang X L, Chen M H, et al. Effect of SIOOA6 over-expression on β-catenin in endometriosis [ J ]. J Obstet Gynaecol Res, 2015, 29(4) : 1.
  • 7Nan Y, Jin F, Yang S, et al. Discovery of a set of biomarkers of human lung adenocarcinoma through cell-map proteomics mad hioinformatics [J]. Med Oncol, 2010, 27(4) : 1398.
  • 8Danish M, Fatima A, Khanam S, et al. Evaluation of the toxic potential of calcium carbide in the third instar larvae of transgenic Drosophila melanogaster ( hsp70-1acZ ) Bg9 [J]. Chemosphere, 2015, 139 (18): 469.
  • 9Miro J, Laaz-ef A M, Rofidal V, et al. FUBP1 : a new protagonist in splicing regulation of the DMD gene [J]. Nucleic Acids Res, 2015, 43(4): 2378.
  • 10Rabenhorst U, Beinoraviciute-Kellner R, Breznicemm M L, et al. Overexpression of the far Upstream element binding protein 1 in hepatocellular carcinoma is required for tumor crowth [J]. Hepatology, 2009, 50(4) : 1121.

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广东医学
2014年 第5期

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