男性正常甲状腺功能促甲状腺激素水平与血脂异常的关系

Relationship between dyslipidemia and thyrotropin with reference range in euthyroid men

目的 研究正常男性人群中血清促甲状腺激素（TSH）与血脂谱之间的关系.方法 调取我院男性健康体检人群资料共230例,按照血清促甲状腺激素（TSH）水平分为2组.A组TSH 0.3-2.5 mU/L 138例,B组TSH 2.5-5.5 mU/L 92例,分析两组间的血脂差异.结果 B组的稳态模型评估的胰岛素抵抗指数（HOMA-IR）及胆固醇（TC）高于A组,1.64±0.54 vs 1.41±0.65,（5.11±0.95） mmol/L vs （4.86±0.85） mmol/L（P〈0.05）.相关分析表明,TSH与TC正相关（r=0.165,P〈0.05）,且经过游离三碘甲状腺原氨酸（FT3）、游离总甲状腺素（FT4）、HOMA-IR等因素的校正后相关性仍然存在.结论 在甲状腺功能正常的男性人群中,TSH为TC升高的危险因素,且独立于甲状腺激素和胰岛素抵抗.

Objective To explore the relationship between dyslipidemia and serum thyrotropin（TSH） with the reference range in euthyroid men. Methods 230 normal male subjects receiving regular medical check-up from our hospital were divided in two groups according to TSH level. TSH 0.3-2.5 mU/L in A group included 138 cases,and TSH 2.5-5.5 mU/L in B group included 92 cases. Two groups were analyzed for the difference in serum lipid. Results B group had higher insulin resistance （HOMA-IR） and total cholesterol （TC）, 1.64 ± 0.54 vs 1.41 ±0.65, （5.11± 0.95） mmol/L vs （4.86±0.85） mmol/L（ P 〈0.05）. TSH was positively associated with TC（ r =0. 165, P 〈0.05） after adjustment of free triiodothyronine（FT3）,free thyroxine（FT4） and HOMA-IR. Conclusion Raised serum TSH seems to be a risk factor of TC in euthyroid men,which is independent of thyroid hormone and insulin resistance.