液相色谱-质谱联用技术在水产品药残分析中的应用

The Application of drug residue detection by Liquid chromatography-mass spectrometry in aquatic products

根据常见水产品兽药残留的检测项目,介绍了几种液相色谱-质谱联用技术在水产品药残检测的应用,总结了其发展趋势。目前,超高效液相色谱被越来越广泛的用于分离系统,电喷雾电离源离子化模式能满足90%以上化合物的要求,三重四极杆质谱仪成为水产品的定量分析的首选仪器,而四极杆-飞行时间质谱仪可成为多种兽药残留全化合物的筛查检测和未知物定性分析的重要手段。

According to the testing items of common aquatic products veterinary drug residues, introduces the applica- tion of several liquid chromatography-mass spectrometry technology in aquatic products drug residue detection： UPLC is used to separate the system more and more widely, ESI ionization mode can meet the requirements of more than 90% com- pounds, TQ/MS has become the preferred instrument of quantitative analysis of water products, and Q-TOF/MS can be- come an important means to screening unknown material and qualitative compound of veterinary drug residues. Its devel- opment trend was summarized.