前列地尔联合羟苯磺酸钙治疗慢性肾衰竭的疗效观察

Clinical observation of Alprostadil combined with calcium dobesilate in treatment of chronic renal failure

目的:观察前列地尔(PGE1)联合羟苯磺酸钙治疗慢性肾衰竭(CRF)的临床疗效。方法:收集盘锦市中心医院自2010年5月-2012年5月住院治疗的CRF患者50例,随机分治疗组(25例)和对照组(25例)。两组慢性肾衰竭常规用药相同,治疗组加用PGE1(10μg,静脉滴注,1次/d)和羟苯磺酸钙(500mg,口服,3次/d)。观察两组慢性肾衰竭患者治疗前后血肌酐(Scr)、尿素氮(BUN)以及24h尿蛋白定量(TP/24h)的变化,并观察不良反应。结果:慢性肾衰竭患者治疗组治疗4周后,Scr、BUN、TP/24h明显低于对照组(P<0.05)。两组慢性肾衰竭患者未见明显不良反应发生。结论:PGE1联合羟苯磺酸钙可有效改善慢性肾衰竭患者的肾功能。

ObjectiveTo observe clinical effects of Alprostadil combined with calcium dobesilate in treatment of chronic renalfailure （CRF）. Methods：50 CRF patients in nephrology department of our hospital from May 2010 to May 2012 were collected andrandomly divided into treatment group （25 cases） and control group （25 cases）. On the basis of the conventional treatment, treatmentgroup was additionally treated with alprostadil injection （10ug, intravenous dripping, qd） and calcium dobesilate （500 mg, orally,tid）, while control group only took the conventional treatment. Renal function indices like serum creatinine （Scr）, urea nitrogen（BUN） and 24-hour urinary protein （quantitative） （TP/24h） were observed for two groups before and after the treatment, and ad-verse reactions were also observed. Results： 4 weeks later, the levels of Scr, BUN, TP/24h in treatment group were significantly lowerthan those of control group （P〈0. 05）. No obvious adverse reactions were found in the two groups. Conclusions： Alprostadil combinedwith calcium dobesilate can effectively improve the kidney function for the patient with CRF.