甲巯咪唑致关节炎综合征一例并文献复习

Arthritis syndrome caused by thyrozol one case-report and literature review

目的报道1例服用甲巯咪唑(商品名赛治)出现抗甲状腺综合征的患者,并进行文献复习。方法对1例30岁女性服用赛治出现抗甲状腺综合征患者的临床资料进行回顾性分析,并复习相关文献。结果本例患者因甲状腺功能亢进症口服赛治(10 mg,tid)治疗,25 d后出现游走性多关节疼痛、活动受限。停用赛治,口服洛索洛芬钠(商品名乐松)治疗,关节疼痛好转。换用丙硫氧嘧啶治疗,无不良反应。结论口服赛治可发生抗甲状腺关节炎综合征,需立即停药。

Objective To report one case of taking thyrozol appears arthritis syndrome patients and a literature review. Methods A 30-year-old female patient with hyperthyroidism appeared arthritis syndrome after starting therapy with the antithyroid drug thyrozol.The patient clinical data were retrospectively analyzed, and review of the literature. Results The patient with hyperthyroidism due to oral thyrozol （10 mg tid） therapy 25 days, her joint happened the migratory joint pain, and limited mobility. Thyrozol was withdrawn.Symptoms disappeared after loxonin was given. Oral therapy was switched to propylthiouracil, no adverse reactions. Conclusion Antithyroid arthritis syndrome can occur when thyrozol therapy for hyperthyroidism. Prompt withdrawal of the antithyroid drug is necessary.