重症患者胰腺外分泌功能不全的研究进展

Recent research progress of pancreatic exocrine insufficiency in critically ill patients

重症患者虽然常常合并胰腺损伤,且胰腺损伤所致外分泌功能不全的直接后果则是营养不良,但迄今未对重症患者胰腺外分泌功能不全的研究引起足够的重视。为此,本文系统回顾了胰腺外分泌功能不全的诊断方法,重症患者胰腺损伤和胰腺外分泌功能不全的流行病学和潜在的高危因素以及胰酶补充治疗的可行性,旨在为重症患者纠正营养不良,改善预后提供新的途径和方法。

Although pancreatic injury is commonly present in critically ill patients, which may lead to pancreatic exocrine insufficiency and thus malnutrition, little attention was paid to pancreatic exocrine insufficiency in patients with critical illness so far. Therefore, we systematically reviewed the progress in diagnostic methods of pancreatic exocrine insufficiency, the epidemiology and risk factors of pancreatic exocrine insufficiency, and the potential role of pancreatic enzyme replacement therapy in critically ill patients. We believe that the correction of pancreatic exocrine insufficiency may contribute to the improvement of malnutrition and prognosis in critically ill patients.