足细胞与哺乳动物西罗莫司靶点

Mammalian target of rapamycin in podocyte

哺乳动物西罗莫司靶点(mTOR)是一种广泛表达的激酶,mTORC1调节细胞增殖与自噬,mTORC2与细胞生存有关,足细胞是一种高度分化细胞,自噬对足细胞生存及老化有保护作用,足细胞自稳有赖于低水平的mTOR活性和高水平的自噬活性,这种平衡的破坏与肾小球疾病的慢性进展密切相关。

Mammalian target of rapamycin （mTOR） is a widely expressed kinase. mTORC1 regulates cell proliferation and autophagy and mTORC2 relates with cell survival. Podocytes are highly differentiated cells. Autophagy protects the podocyte survival and keeps away from ageing. Podocyte stability depends on the low level of mTOR activity and a high level of cell autophagy activity of the cell. Unbalance of podocyte stability is closely related to the development of chronic glomerular disease.