布托啡诺对兔定量药物脑电图的影响

Effects of butorphanol on QPEEG in rabbits

目的：观察布托啡诺对兔定量药物脑电图（ QPEEG）的影响。方法24只健康成年家兔随机分为4组（n＝6），分别静脉注射生理盐水1 ml· kg^-1及布托啡诺0．1、0．5、2．5 mg· kg^-1；应用数字脑电地形图仪，分别记录给药前30 s，给药后30 s及给药后1、2、3、5 min兔左、右大脑额、顶、枕、颞8个脑区QPEEG，采用功率谱分析，分析给药前后QPEEG的变化。结果与给药前比较，生理盐水组及布托啡诺0．1 mg· kg^-1组、0．5 mg· kg^-1组各脑区各频段功率百分比均无明显变化，2．5 mg· kg^-1组左脑额、顶、枕区α1频段功率百分比在30 s～5 min内减少（P＜0．05）。结论小、中剂量布托啡诺对家兔QPEEG各脑区各频段功率百分比无明显影响，大剂量布托啡诺可以减少左脑额、顶、枕区α1频段功率百分比。表明布托啡诺与阿片受体完全激动剂在大脑皮质的作用部位、频段上存在着差别。

Objective To investigate the effects of butorphanol on quantitative pharmaco -electroencephalography （QPEEG） in rabbits.Methods Twenty-four healthy rabbits were randomly divided into four groups （n=6）, where rabbits in each group were intravenously injected with 1 ml/kg normal saline, 0.1 ml/kg, 0.5 ml/kg or 2.5 ml/kg butor-phanol.Then a digital EEG system was adopted to record the changes of QPEEG in eight encephalic regions 30 seconds before and 30 seconds, 1, 2, 3, 5, 10, 15, 20, 25, 30 minutes after injection.Results Compared with the baseline, there is no remarkable change in the normal saline group , and 0.1 mg/kg and 0.5 mg/kg butorphanol group as to the percentages of various band powers .The percentages of 1 band power in the frontal , parietal, and occipital areas of the left brain of 2.5 mg/kg butorphanol group are noted down within 30 seconds to 5 minutes （P〈0.05）.Conclusion Low and medium doses of butorphanol perform no obvious effect on the percentage of various band powers of QPEEG of rab -bits.A high dose of butorphanol can decrease the percentages of 1 band power in the frontal , parietal, and occipital areas of the left brain.The data indicate different sites of action and band powers when butorphanol interacts with an opioid re -ceptor agonist in the cerebral cortex .