温阳复方对高脂高糖饮食诱导的肥胖大鼠血脂的影响

Effects of Warming-Yang Compound Chinese Traditional Medicine on Seral Lipids in High Fat and Sugar Diet-induced Obese Rats

为研究温阳为主中药复方对肥胖大鼠体重和血脂的影响,探讨温阳法治疗肥胖的可行性,本试验取SD肥胖大鼠成5组,分别为模型组、阳性药二甲双胍组、温阳复方组、温阳药对组、阴性复方组,每天灌胃给药1次,给药8周下腔静脉取血测定相关指标。结果表明,温阳复方能有效降低肥胖大鼠的TG、TC、LDL,并升高HDL(P<0.05)。说明温阳中药复方具有能够减轻体重、调整脂代谢的作用。

To study the effect of Warming-Yang compound Chinese traditional medicine （WY-CCTM） on decreasing of serum lipids and body mass index in obese rats,obese rats were divided into 5 groups, model control, metformin-treated group, WY-CCTM-treated group, Warming-Yang herb-partners-treated group and negative-CCTM-treated group. All the rats were administrated once a day for 8 weeks. At the end of the study, rats were all scarified and blood samples were got to determine the serum levels of TG,TC,LDL and HDL. The results shoued that WY-CCTM could reduce TG, TC, LDL levels and increase HDL levels in obese rats signifi ulate lipid metab cantly, compared with the model control group. WY-CCTM could reduce body weight, reg olism in obese rats.