羊痒病诊断方法研究进展

Progress on Diagnostic Metheds of Scrapie

羊痒病是传染性海绵状脑病的原模型,主要感染绵羊、山羊和欧洲盘羊,羊痒病至今还没有有效的治疗措施。因此,快速、敏感、特异性的诊断方法对羊痒病的监测和防控有着极其重要的意义。世界动物卫生组织推荐的羊痒病诊断方法包括免疫印迹、组织病理学、免疫组化及毒株鉴定。2012年,我国将羊痒病列入重大外来动物疫病监测计划。与其他的朊蛋白病一样,羊痒病是一种渐进性、致死性的中枢神经系统变性疾病。目前认为传染性海绵状脑病的病原因子是一种编码宿主蛋白的PrPC转变为异常细胞型PrPSC沉积在大脑,导致疾病。论文对羊痒病诊断技术的研究进展做一概述,为该病的进一步研究及防控提供参考。

Scrapie is a naturally occuring transmissible spongiform encephalopathy （TSE） in sheep, goats and mufflons,and there is no effective treatment measures. Therefore, rapid,sensitive, specific diagnostic methods are very important for monitoring and controlling of scrapie. The diagnosis methods of scrapie recommended by the world animal health organization include immunoblotting, histopathology, immunohisto-chemistry and strain identification. In 2012, scrapie was included in China foreign animal disease surveillance plan. Like all other prion diseases, scrapie is a neurodegenerative progressive and eventually fatal disease. It is characterized by the accumulation of an abnormal isoform （PrPso） of host encoded prion protein （PrPc） in the central nervous system which leads to progressive neurodegeneration and death. This article reviewed the recent progress in the areas of the diagnoses of scrapie for references of study and control.