标准剂量瑞舒伐他汀与辛伐他汀治疗不稳定型心绞痛患者的疗效比较

Curative Effects Comparison of Standard Dose Rosuvastatin and Simvastatin in Unstable Angina Pectoris Patients

目的:探讨标准剂量瑞舒伐他汀与辛伐他汀在不稳定型心绞痛患者治疗中的临床疗效差异。方法:选取通过冠状动脉造影确诊为冠心病不稳定型心绞痛的80例患者,随机分为A组(口服瑞舒伐他汀片10 mg/d)40例,B组(口服辛伐他汀片40 mg/d)40例,治疗8周后比较两组心绞痛缓解有效率及调节血脂效果差异。结果:(1)A组患者心绞痛缓解总有效率(92.5%)高于B组(86.7%)(P<0.05)。(2)两组患者总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)均较治疗前显著降低(均P<0.05);且A组患者TC和LDL-C值分别较B组降低(均P<0.05)。结论:瑞舒伐他汀治疗不稳定型心绞痛患者的临床效果优于辛伐他汀。

Objective：To investigate the diffent efficacy of standard dose Rosuvastatin and Sim-vastatin in patients with unstable angina pectoris. Methods：Chosed 80 patients with unstable angina pectoris diagnosed by coronary artery angiography in the affiliated hospital of Jianghan University from January 2011 to December 2012 and divided into A group（40 patients）and B group（40 pa-tients）in randomized controlled methods,A group taken Rosuvastatin 10mg once daily,B group tak-en Simvastatin 40mg once daily,to compare the remission rate of angina pectoris and the effect of blood-fat regulating after treatment of eight weeks. Results：（1）The Rosuvastatin group（92.5%）has higher total clinical remission rate than Simvastatin group（86. 7%）（P〈 0.05）.（2）The two groups have lower total cholesterol（TC）and low density lipoprotein cholesterin（LDL-C）than those before the treatment（P〈 0.05）. The Rosuvastatin group have higher reduction rate of TC and LDL-C than Simvastatin group（P〈 0.05）. Conclusion：Rosuvastatin is superior to Simvastatin in patients with unstable angina pectoris.