摘要
脂联素(adiponectin,APN)是脂肪细胞分泌的一种内源性生物活性多肽或蛋白质。近年研究发现,脂联素除在胰岛素的调节、心血管的稳态维持方面起作用外,对危重患者,尤其是脓毒症患者的疾病严重程度的预警、治疗方面可能有一定作用。研究发现,危重患者脂联素水平较健康人群下降,且下降程度与疾病预后相关,在脓毒症中,脂联素可能作为脓毒症的预警指标或预后指标;脂联素在炎症反应中的机制可能是通过抑制NK-κB等信号通路抑制巨噬-单核细胞系统活性有关。尽管现有资料尚有限,但已经提示脂联素在危重病人代谢改变中可能起重要作用,为危重病人的诊断和治疗提供新的思路。
Adiponectin,a cytokine produced by adipose tissue,has been shown to have a role in metabolism and inflamma- tion. In recent years,reseachers have found that adiponectin may act as an biomarker in the critical illness or sepsis. They tbund adiponectin decreased in critical ill patients than that in the health control and correlated with the prognosis of disea- ses. In septic patients,adiponectin may act as a diagnotie or prognotic biomarker. Adiponectin may inbibitted the activities of macrophages-monocytes through inhibitting the NK-KB pathway. Respecting the limited data,it is has shown that adiponectin has played an important role in the changes of metabolism in critical illness and contributed some new ideas to the diagnosis amt treatment of＇ critical illness.
出处
《创伤与急危重病医学》
2014年第1期18-22,共5页
Trauma and Critical Care Medicine
关键词
危重病
脓毒症
脂联素
critical illness
sepsis
adiponectin
