广州市社区人群流感抗体水平与人际接触状况的相关性分析

An international collaborative study on influenza viruses antibody titers and contact patterns of individuals in rural and urban household of Guangzhou

目的 探讨广州市社区人群流感抗体水平与人际接触状况的相关性.方法 采用Google数码地图随机抽取广州市行政区域范围内研究点,受检者接受问卷调查并抽取静脉血检测甲型流感（H3N2、H1Nl）抗体.结果 （1）Google数码地图随机选取50个点中符合研究入选条件40个（856户家庭2 801人）作为研究对象,实际参加1 821人（65.0％）,乡村和市区人群分别占77.3％（1 407/1 821）和22.7％（414/1 821）,以18～59岁年龄段为主,其次为≥60岁老年人,2～17岁组比例最低;（2）愿意提供血样者占78.1％（1 423/1 821）,H3N2和H1N1流感病毒抗体阳性率与年龄密切相关,以2～17岁年龄组最高;（3）受检人群间皮肤或近距离人际接触频率甚高,每天接触≥10人者高达49.8％ ～ 72.6％,无零接触者,且以6～17岁组比例最高;相对于工作日,休息日接触人数较少.结论 广州地区社区人群H3N2和H1N1流感病毒抗体阳性率以及人际间近距离接触频率均与年龄有关.

Objective To describe the influenza viruses antibody levels and contact patterns of individuals in rural and urban regions of Guangzhou and to understand how contact patterns and other factors would correlate with the levels on the titers of antibody.Methods ＂Google Map＂ was used to randomly select the study points from the administrative areas in Guangzhou region.Each participant was required to provide 5 ml blood serum sample to be tested against different strains of H1N1 and H3N2 influenza viruses.Results 1） Using ＂Google map＂,50 study points were selected but only 40 study points would meet the inclusion criteria.The cohort of this study consisted 856 households with 2 801 individuals.1 821 participants （65% of the total number individuals in the cohort） completed the questionnaires.Among the 1 821 participants,77.3% （1 407/1 821） and 22.7%（414/1 821） of them were from rural and urban areas respectively.There were more male participants in the rural but more female participants in the urban regions.Majority of the participants were from age group 18-59 followed by group 60 with aged 2-17 the least,in both rural and urban areas.2） 78.1% （1 423/1 821） of the participants provided their serum samples.There appeared a strong correlation between age of the participants and the strength of their antibodies against that strain when a strain first circulated.In particular,seroprevalence was the highest at the age group 2-17.3） ‘ Contact’ was defined as persons having physical touch or/and conversation within one meter with the participants.Participants reported all having had large number of contacts.The proportion of participants having contacts with ten persons or above was the highest,ranging from 49.8% to 72.6%,particularly in age group 6-17.Compared to weekdays,participants had fewer contact persons on weekends.Conclusion There was a strong correlation between the age of participants at the time when the strains first circulated and the seroprevalence against influenza virus strains of H 1N 1 and H3N2.Also,age of the participants and the frequencies of their contacts to people,was also correlated.