大气细颗粒物的健康危害机制及拮抗作用研究进展

Adverse health effects and mechanism of airborne fine particulate matter and the antagonistic effects of bioactive substances:a review of recent studies

流行病学研究证实大气细颗粒物(PM2.5)与多种呼吸道疾病及心血管疾病的发病率与死亡率密切相关。PM2.5的毒性损伤机制除了与炎性损伤、氧化损伤相关外,还与多条细胞内信号通路有关,已成为研究的热点之一。生物活性物质因具有的抗氧化等活性已被应用于拮抗PM2.5毒性作用的研究中。因此,该文就PM2.5健康危害的流行病学研究及对细胞内信号通路的影响和生物活性物质对PM2.5的拮抗作用的研究进展进行综述。

Epidemiological studies demonstrated that exposure to airborne fine particulate matter （PM2.5） is closely associated with increased respiratory and cardiovascular morbidity and mortality. It is known that fine particulate matter can induce inflammatory, responses and increase oxidative stress, and several intracellular pathways are involved, which has become one of the hot topics in the field of environment and health. Bioactive compounds with antioxidant activities have been used in studies against PM2.5. The recent epidemiology studies and impact on cell signals of PM2.5 and some bioactive compounds against PM2.5 were reviewed in the present paper.