胶质细胞源性神经营养因子在肠神经系统中的作用

Study advancement of glial cell line-derived neurotrophic factor in the enteric nervous system

胶质细胞源性神经营养因子（GDNF）是一类调节肠神经系统存活、分化、定植及损伤修复的蛋白因子，在小儿先天性巨结肠、肛门直肠畸形等肠神经系统发育异常疾病中的研究已得到证实，但其具体调控机制不详；有研究发现GDNF／GFRa1／RET和GDNF／GFRa1／NCAM通路可能参与肠神经系统发育与成熟，它们的异常将影响肠神经干细胞的分化、增殖及移行，引起肠神经元解剖结构和功能的异常，导致疾病发生。

Glial cell line-derived neurotrophic factor（GDNF） is a kind of protein factor which can regulate the enteric nervous system in survival, differentiation, colonization and injury repair. It has been confirmed in the disorders of the enteric nervous system, sueh as hirschsprung and anorectal malformations, but the specific mechanism in regula- tion of this factor is still unknown. Studies have found that GDNF/GFRal/RET and GDNF/GFRal / NCAM pathway may be involved in the growth and maturation of the enteric nervous system, the disorders of those pathways above may lead to diseases by affecting the differentiation, proliferation and migration of intestinal neural stem cells, causing dys- functions in the anatomical structure and function of the intestinal neurons.