Kasai手术治疗胆道闭锁研究进展

Current option of clinical research in biliary atresia treated with Kasai procedure

胆道闭锁（BA）以胆道系统进行性炎症和纤维性梗阻为特征，在新生儿期出现梗阻性黄疸症状，如果不能有效治疗最终肝纤维化进展导致终末期肝衰竭和死亡。Kasai手术是治疗BA主要的手术方法，但并非所有病例在术后都获得黄疸清除和自体肝存活，为提高治疗效果需要在手术时机、手术方式、术后用药以及并发症的预防和处理上进行优化，现对目前相关临床研究和治疗现状进行总结。

Biliary atresia （BA） is characterized of progressive inflammation and obstruction with fibrosis in biliary system and presents symptoms with obstructive jaundice in neonatal period, if its treatment is not ineffectively may lead to progressive liver fibrosis, end-stage liver failure and die within 2 years. Kasai procedure is the major method in BA treatment, but not all cases have postoperative jaundice clearance and survive with native liver, it is need to opti-mize the choice of surgical time and methods, postoperative protocol with medicine, prevention and treatment of compli- cations for improving the postoperative therapeutic effect. In this paper, the current option of clinical research and statue in Kasai procedure were summarized.