溴氰菊酯亚慢性染毒对小鼠空间学习记忆的影响

Effect of sub-chronic exposure to deltamethrin on spatial learning and memory in mice

目的 研究溴氰菊酯（DM）亚慢性染毒对小鼠空间学习记忆的影响.方法 清洁级雌性昆明小鼠60只,分为4组,通过灌胃连续染毒60 d.采用Morris水迷宫实验评价小鼠的空间学习记忆能力.结果 DM亚慢性染毒后,定位航行试验中第5天溶剂对照组和各剂量组小鼠的平均逃避潜伏期分别为（12.20±6.5）s、（14.99±5.4）s、（15.64±8.3）s、（22.71±6.2）s.两两比较高剂量组小鼠的逃避潜伏期明显高于低剂量组（P=0.0041）和溶剂对照组（P=0.019）.空间探索试验,与溶剂对照组（5.87±1.55）次和低剂量组（4.90±1.41）次相比,中剂量组和高剂量组小鼠穿越原平台位置的次数分别为（3.40±112）次和（2.93±1.53）次,显著低于溶剂对照组和低剂量组（P,＜0.05）.结论 DM亚慢性染毒可引起小鼠空间学习和记忆功能损伤.

Objective To study the effect of sub-chronic exposure to dehamethrin（DM） on the behavior of mice in learning and memory. Methods 60 Female SPF Kunming mice were randomly divided into 4 groups and given DM by gavaging for 60 days. Morris water maze （MWM） was used to evaluate spatial memory in mice. Results After exposure to DM,the escape latency of the solvent control group and the treatment groups were （ 12. 20± 6.5） s, （ 14.99 ± 5.4） s, （ 15.64 ± 8.3 ） s, （ 22.71 ± 6.2） s on the fifth day. The escape latency of the high-dose group was higher than those of the low-dose group （P= 0.0041） and the solvent control group （P= 0.019） in the navigation test. The number of crossing position of the platform in the high-dose group （ （ 2.93± 1.53 ） times） and the middle-dose group （（3.40± 1.12）times） were lower than that in the solvent control group （（ 5.87±1.55 ） times） and the low-dose group （ （4.90± 1.41 ） times） （P〈 0. 05 ） . Conclusion Sub-chronic exposure to DM can damage the spatial learning and memory of mice.