甲硝唑氯化钠注射液在全肠外营养液中的稳定性

Evaluation on the stability of metronidazole-sodium-chloride in the total parenteral nutrient solutions

目的:考察甲硝唑氯化钠注射液与多组分全肠外营养液的配伍稳定性。方法:根据临床处方配比,将甲硝唑氯化钠注射液加入多组分全肠外营养液,室温下放置24h,并在0,2,4,6,8,10,12,16,24h时对配伍液的外观性状、脂肪乳粒径大小及分布、pH值、渗透浓度进行考察,同时采用高效液相色谱法测定各时间点甲硝唑的含量。结果:24h内配伍液的外观、脂肪乳粒径大小及分布、pH值、渗透浓度均无显著性变化。甲硝唑在多组分全肠外营养液中的含量也未发生明显改变。结论:24h内室温条件下,甲硝唑氯化钠注射液在多组分全肠外营养液中稳定。

OBJECTIVE To investigate the compatible stability of metronidazole-sodium-chloride injection mixed with total parenteral nutrient（TPN）solution. METHODS Metronidazole-sodium-chloride injection mixed with TPN solution at room tem- perature for 24 h. The appearances of the mixture were observed at 0,2,4,6,8,10,12,16,24 h and the change of pH value was evaluated. At the same time, osmolality and the accumulation of fat emulsion drops were observed and measured, too. The contents of metronidazole were determined by HPLC. RESULTS There was no significant change in the appearance, pH value and osmolality of nutrient. The accumulation of fat emulsion drops was no significant change, too. No change was observed in the contents of metronidazole in totaI parenteral nutrient within 24 h. CONCLUSION At room temperature metronidazole-sodi- urn-chloride in TPN is stable within 24 h.