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鞘氨醇-1-磷酸-1型受体选择性配体研究进展 被引量：1

Progress in research of selective S1P_1 receptor ligands
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摘要 本文主要从鞘氨醇-1-磷酸1型受体(S1P1R)选择性配体结构分类的角度,综述了S1P1R配体的研究进展;结合近几年已经入临床试验的S1P1R选择性调节剂,加入了在相关治疗领域的应用,特别是用于流感病毒引发的肺部炎症;从受体结构出发,讨论了S1P1R配体的构效关系,并展望S1P1R选择性配体药物的开发前景。 In this review, the latest progress in different chemical types of S1P1RL were over-viewed. According to the clinical research of several candidate drugs, some related therapies were added to this review. Meanwhile, in perspective of the structure of S1P1R, the SARS of S1P1RL was discussed and the investigation prospect of S1P1RL drugs were described.
作者 李忠堂 从玉文 张庆林 杨日芳
机构地区 军事医学科学院毒物药物研究所 军事医学科学院放射医学研究所
出处 《中国新药杂志》 CAS CSCD 北大核心 2014年第7期802-810,818,共10页 Chinese Journal of New Drugs
基金 国家自然科学基金(81272997) 国家"重大新药创制"科技重大专项(2013ZX09J13102-02C)
关键词 鞘氨醇-1-磷酸1受体 选择性配体 构效关系 免疫抑制 多发性硬化 S1P1 receptor；selective ligands；structure activity relationship；immune inhibition；multiple sclerosis
分类号 R979.5 [医药卫生—药品]
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参考文献28

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中国新药杂志
2014年 第7期

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