脑缺血半暗带的分子影像学

Molecular imaging of cerebral ischemic penumbra

分子影像学在缺血性卒中神经影像学领域发展较快，许多研究已显示了其在缺血性卒中脑血流监测和脑组织代谢测定方面的价值。缺血半暗带是急性缺血性卒中再灌注治疗的基础，以磁共振灌注加权成像／弥散加权成像不匹配为代表的成像方法因快速、可用性强，被广泛用于反映缺血半暗带，但仅能反映半暗带组织的血流情况；相比之下，分子影像学技术能在活体内对细胞和分子水平的生物学过程进行描述和测量，因而可从组织代谢角度更加准确地反映半暗带组织。

Molecular imaging develops faster in the field of neuroimaging of ischemic stroke. Many studies have shown that its values in the aspects of cerebral blood flow monitoring during ischemic stroke and brain tissue metabolism. Ischemic penumbra is the basis of reperfusion therapy for acute ischemic stroke. The imaging methods, including magnetic resonance perfusion-weighted imaging/diffusion-weighted imaging mismatch, have been widely used to reveal ischemic penumbra because of their fast and strong availability. However, they can only reveal the blood flow of penumbra tissue. By contrast, molecular imaging technology can describe and measure the in vivo biological processes on the cellular and molecular levels, thus it can more accurately reveal the penumbral tissue.