补肾健脾法治疗体外受精胚胎移植中卵巢低反应临床研究

Treatment of poor ovarian response in IVF-ET by supplementing kidney and strengthening spleen method

目的观察补肾健脾法治疗体外受精胚胎移植(IVF-ET)中卵巢低反应的临床疗效。方法将78例卵巢低反应患者随机分为中药组(38例)和对照组(40例)。在进入控制性超促排卵(COH)流程之前,中药组给予3个月的补肾健脾中药治疗,对照组不予治疗。检测两组治疗前后基础卵泡刺激素(bFSH)、窦卵泡计数(AFC),及予来曲唑微刺激方案后两组获卵数、优质胚胎数、妊娠率情况。结果①治疗后中药组bFSH水平较治疗前下降(P<0.01),AFC增多(P<0.01);且两组比较有统计学差异(P<0.01)。②治疗后中药组获卵数增加且多于对照组(P<0.01),中药组优质胚胎数也较治疗前增多(P<0.01)。③治疗后中药组临床妊娠率较对照组有增高趋势,但无统计学差异(P>0.05)。结论补肾健脾法可改善IVF-ET中卵巢低反应,提高卵巢储备功能。

Objective To observe the clinical efficacy of supplementing kidney and strengthening spleen method in treating poor ovarian response （POR） in IVF- ET. Methods Seventy-eight cases with POR were randomized into Chinese medicine group （ n = 38 ） and control group （ n = 40）. The Chinese medicine group was treated with supplementing kidney and strengthening spleen herbs for 3 months, and without any treatment for control group. The follicle-stimulating hormone （FSH） and antral follicle account （AFC） were evaluated, and the numbers of retrieved oocytes, high quality embryos and pregnancy rate were recorded after stimulated by Letrozole. Results ① The bFSH level was reduced in Chinese medicine group after treatment （ P 〈 0.01 ） , and the numbers of AFC was increased （P 〈0.01 ）. ② After treatment, the number of retrieved oocytes was increased and significantly higher than that of the controls （P 〈0.01 ）. The number of high quality embryos was increased significantly （P 〈0.01 ）. ③ Compared with the control group, the clinical pregnancy rate has an increasing tendency in Chinese medicine group, but without significant difference （ P 〉 0.05 ）. Conclusion Supplementing kidney and strengthening spleen method can improve poor ovarian response in IVF-ET and improve ovarian reserve function.