α-干扰素联合拉米夫定治疗慢性乙型肝炎的疗效观察

The Curative effect observation of α-interferon combined with lamivudine in the treatment of chronic hepatitis B

目的 探讨分析a-干扰素联合拉米夫定治疗慢性乙型肝炎的疗效.方法 选取2008年1月-2010年1月在我院接受治疗的慢性乙型肝炎患者60例.随机将患者分为治疗组和对照组各30例,对照组口服拉米夫定100mg/d;治疗组a-干扰素500万单位肌肉注射,隔日一次,联合拉米夫定口服,100mg/d.结果 2组治疗时间均为24个月,治疗组有效率为96.67％,显著高于对照组的70％,两组比较P＜0.05,差异具有统计学意义.结论 a-干扰素联合拉米夫定治疗慢性乙型肝炎疗效较单纯应用拉米夫定治疗显著,值得临床推广应用.

Objective Discuss and analyze the efficacy of α- interferon combined with lamivudine in the treatment of chronic hepatitis B. Methods Choose 60 cases of chronic hepatitis B diagnosed at our hospital from January 2008 to February 2010. 60 patients were randomly divided into treatment group and control group, each group was 30 cases. The patients in the control group were given lamivudine 100mg PO daily; the patients in the treatment group were given α- interferon 5000,0001U IM ,once every other day with combination of lamivudine 100mg PO daily. Result Both of the 2 groups were treated for 24 months. The effective rate of the treatment group was 96.67%, significantly higher than that of the control group （70%）. The difference between the treatment group and control group was statistically significant （P〈0.05）.Conclusion The combination therapy of α- interferon and lamivudine in the treatment of chronic hepatitis B was of significant efficacy and worth to clinical application.input of science and technology played a positive role in the development of pharmaceutical economy and Chinese pharmaceutical industry was a sunrise industry with low input, high output and low energy consumption.