2型糖尿病及糖尿病肾病患者糖化白蛋白的临床检测分析

Clinical analysis of glycated albumin in the patients with type 2 diabetes mellitus and diabetic nephropathy

目的探讨糖化白蛋白(GA)以及其他代谢标志物水平检测对2型糖尿病合并肾病患者的临床意义,为2型糖尿病合并肾病患者的临床诊治提供有效依据。方法选取2010年8月至2012年7月在我院接受临床治疗的2型糖尿病患者120例,选取其中合并肾病患者60例作为观察组,另外未合并肾病的患者为对照组,并选取同期进行体检的60例健康人作为健康组,检测3组的GA、糖化血红蛋白(HbA1c)的含量,并对观察组与对照组患者采取常规治疗,测量治疗后患者空腹血糖、餐后2 h血糖以及GA和HbA1c的含量,进行比较分析。结果观察组与对照组患者的GA与HbA1c水平显著高于健康组(P<0.05),观察组患者的GA值显著高于对照组,而HbA1c值则无显著差异性;采取有效治疗后,2组患者的血糖水平得到有效控制,观察组GA水平低于对照组而HbA1c水平与对照组无差异。结论通过检测糖尿病患者血清GA含量,不仅可以对合并肾病的患者做出有效诊断,还可以作为衡量临床治疗效果的标准,以此来提高糖尿病合并肾病的治疗效率。

Objective To explore the clinical significance of the levels of glycated albumin （GA） and other metabolic markers in the patients with type 2 diabetes mellitus and diabetic nephropathy. Methods 120 patients with type 2 diabetes from August 2010 to July 2012 in our hospital were selected and divided into two groups,60 patientes with diabetic nephropathy were treated as observation group,60 cases without diabetic nephropathy were treated as control group. And 60 healthy people were enrolled as healthy group. The levels of GA, glyeosylated hemoglobin （HbAlc）were measured in three groups. Conventional therapy were given to the observation group and control group, and the levels of GA, HbAlc, fasting blood glucose, 2 h postprandial blood glucose in tWO groups were detected and compared. Results The levels of GA and HbAlc in observation group and control group were significantly higher than those in the healthy group （P〈0. 05 ）, and the level of GA in observation group was significantly higher than that in control group.Blood glucose levels of observa- tion group and control group were effectively controlled, and there was significant difference in the level of GA between ob- servation group and control group. Conclusions The detection of serum GA in diabetes patients with diabetic nephropathy is beneficial not only for diagnosis, and also for evulation of efficacy.