CD_(151)及整合素α_3β_1蛋白在非小细胞肺癌中的表达及意义

CD_(151) and Integrin α_3β_1 Expression in Non-small Cell Lung Cancer

目的探讨CD151及整合素α3β1蛋白在非小细胞肺癌中的表达及意义。方法采用免疫组化法检测78例非小细胞肺癌和22例肺良性病变组织中CD151和整合素α3β1蛋白的表达,分析两者之间的关系,并结合临床资料进行分析。结果 CD151、α3β1蛋白在非小细胞肺癌组织中的表达阳性率分别为57.7%(45/78)和51.3%(40/78),高于肺良性病变组织的18.2%(4/22)和22.7%(5/22),差异有统计学意义(χ2=10.72、5.653,P=0.001、0.017)。CD151蛋白表达与病理分型、转移淋巴结数目有关。整合素α3β1蛋白表达与是否吸烟、病理分型、转移淋巴结数目有关。CD151与α3β1在非小细胞肺癌组织中的表达呈正相关(r=0.464,P=0.000)。Cox回归分析表明CD151蛋白是影响非小细胞肺癌预后的独立危险因素(P=0.014)。结论 CD151和整合素α3β1蛋白在非小细胞肺癌组织中的表达均高于肺良性病变组织,两者在非小细胞肺癌中的表达呈正相关,CD151蛋白阳性表达预后差。联合检测CD151和整合素α3β1蛋白可为判断非小细胞肺癌的生物学行为、预后提供参考依据。

Objective To investigate the clinical significance of CDm and integrin or3131 expression in non - small cell lung cancer （NSCLC）. Methods Immunohistoehemical staining （SP） was applied to determine the expressions of CDm and integrin or3131 in tissues of 78 NSCLC cases （ group A） and 22 eases of benign pulmonary lesion （ group B） and analyze the cor- relation between 2 groups. Results The positive expression rate of CDm and eq 131 in group A were 57.7% （45/78） and 51.3% （40/78） , higher than those of group B 18.2% （4/22） and 22. 7% （5/22） 3, the difference were significant （X2 = 10. 72, 5. 653, P =0. 001, 0. 017）. CDm expression was related to pathological typing, number of lymph nodes, integrin x3131 to smoking, pathological typing, number of lymph nodes. CDII was positively correlated with a3131 （r = 0. 464, P = 0. 000）. Cox regression analysis showed that CDm protein is an independent risk factor influencing the prognosis of NSCLC （P =0. 014）. Conclusion The expressions of CD151 and integrin 0t131 are higher in group A than in group B. They are positively correlated. The prognosis of CDm positive expression is poor. Combined CDII and integrin a3131 can provide basis for judgment of biological behaviors and prognosis.