急性百草枯中毒肺损伤的激素治疗

Glucocorticoid Treatment in Lung Injury Induced by Acute Paraquat Poisoning

百草枯作为一种有机杂环类接触性除草剂,对人畜均有非常强的毒性,对于急性百草枯中毒目前尚无特效解毒药。肺脏是百草枯中毒损害的主要靶器官,针对百草枯中毒肺损伤激素治疗的研究有很多,但关于激素剂量及联用药物的选择等尚缺乏统一标准,本文就激素对急性百草枯中毒肺损伤的治疗作用、激素种类选择、激素剂量选择、激素联用药物选择的研究进展进行综述。

As one of heterocyclic organic herbicides, paraquat has a very high toxicity to both human and livestock, however, so far, there is no specific antidote against acute paraquat poisoning. Lung is one of the main target organs of paraquat poisoning. There are many studies on glucocorticoid treatment in lung injury induced by paraquat poisoning, but the studies on u- nified standards about selection of glucocorticoid dosage, combined use of drugs and so on are relatively scarce. In this paper, we reviewed the therapeutic effect of glucocorticoid on lung injury induced by acute paraquat poisoning, and discussed the selec- tion of glucocorticoid types, dosage and combined use of drugs.