多囊卵巢综合征患者尿酸与胰岛素抵抗的关系研究

Relationship between Uric Acid and Insulin Resistance in PCOS Patients

目的 探讨多囊卵巢综合征（PCOS）患者尿酸与胰岛素抵抗（IR）的关系.方法 选取2012年6月-2013年6月就诊于厦门大学附属第一医院生殖科门诊的65例PCOS患者为研究对象,按照胰岛素抵抗指数（HOMA-IR）分为IR组41例和非胰岛素抵抗（NIR）组24例.分别于月经周期第2~4天上午空腹抽取肘静脉血,测定黄体生成素（LH）、卵泡刺激素（FSH）、睾酮、空腹胰岛素（FINS）、空腹血糖（FBG）、三酰甘油（TG）、胆固醇（TC）、尿酸（UA）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）水平,并计算体质指数（BMI）,比较两组各项指标.结果 IR组BMI及FBG、FINS、UA水平高于NIR组（P＜0.05）;BMI、FINS、FBG、UA与HOMA-IR呈正相关（r值分别为0.48、0.95、0.25、0.42,P＜0.05）.结论 UA与 IR 关系密切,二者在PCOS患者代谢综合征的发生、发展中共同起促进作用.

Objective To explore the relationship between uric acid （UA） and insulin resistance （IR） in patients with Polyeystie ovary syndrome （PCOS）. Methods Sixty -five PCOS patients admitted to this hospital from June 2012 to June 2013 were divided, according to insulin resistance index （HOMA -IR）, into groups IR （n = 41 ）, non -IR （n = 24）. Fast- ing venous blood was drawn on days 2 ~ 4 of menstrual cycle to determine the levels of luteinizing hormone （ LH）, follicle stimu- lating hormone （ FSH）, testosterone （ T）, fasting insulin （ FINS）, fasting blood glucose （ FBG）, triglyeeride （ TG）, cho- lesterol （TC）, low density lipoprotein （LDL）, and calculate BMI. The above indexes were compared between 2 groups. Re- sults BMI, and levels of FPG, FINS, UA were higher in IR group than in non - IR group （P 〈 0. 05）. BMI, FINS, FPG, UA were positively with HOMA - IR （ r = 0.48, 0. 95, 0.25, 0. 42, respectively, P 〈 0.05 ）. Conclusion UA is closely related with IR, both play a promotive role in occurrence and development of metabolic syndrome in PCOS patients.