高密度脂蛋白与冠心病的关系研究进展

THE ADVANCES OF STUDYING THE RELATION OF HIGH DENSITY LIPOPROTEIN CHOLESTEROL AND CORONARY HEART DISEASE

流行病学调查、实验研究和临床观察发现 ,血浆高密度脂蛋白胆固醇作为一个独立的预测因素与冠心病的发病率呈负相关 ,HDL促进循环中的胆固醇向肝脏转运即“逆向胆固醇转运” ,HDL中的两种酶 -二乙基对硝基苯磷酸酯酶和血小板激活因子乙酰水解酶能够降低氧化HDL的形成 ;通过戒烟、降低到理想体重、规律的需氧锻炼、药物治疗 ,能绝对或相对的升高HDL -c浓度 ,降低冠心病的发病率。

The epidemiological investigation,experimental and clinical studies demonstrated that the high density lipoprotein cholesterol was an independent predictor of coronary heart disease,low HDL cholesterol concentrations appear to be associated with increased mortality of coronary heart disease,HDL transports excess cholesterol to the liver by reverse cholesterol transport.The two enzymes of HDL,paraoxonase and platelet-activating factor acetylhydrolase appear to diminish the formation of the highly atherogenic oxidized LDL.In terms of elevating HDL cholesterol,cessation of cigarette smoking,reduction to ideal body weight,and regular aerobic exercise all appear important,medications treatment,decrease incidence of coronary heart disease.