大黄对老年Ⅱ型糖尿病尿蛋白排泄率的影响

Effect of Rheum Officinale on Urine Albumin Excretion in Aged Patients with NIDDM

目的 :观察大黄对老年Ⅱ型糖尿病尿白蛋白排泄率的改变。方法 :94例年龄≥ 60岁的NID DM患者伴微量白蛋白尿 ,分为三组 ,分别应用captopril、大黄及两药联合治疗 ,比较治疗前、治疗 2W和4W尿白蛋白排泄率。结果 :应用captopril 2W即发挥降低UAER作用 ( 95.1± 9.8比 82 .7± 8.8,P <0 .0 5) ,大黄治疗 2W对UAER无明显改变 ,4W与captopril效果相似 ( 72 .3± 9.6比 73.3± 9.2 ,P >0 .0 0 1 ) ,两药联合应用效果最佳 ( 4 2 .3± 1 1 .6,P <0 .0 0 1 )。结论 :大黄有降低老年NIDDM患者尿白蛋白排泄的作用 ,与aptopril联用效果最好。

Objective:Invegtigate the effect of Rheum officina on urine albumin excretion rate in aged patients with NIDDM.Methods 94 aged NIDDM Patients with microalbuminuria were randomly divided into three treatment.groups(captopr Rheum officinale,and combination).UAER were detetmined and compared before and after Results UAER was singificantly reduced in all groups after 4 weeks treatmint.The combining group showed more effective than other two groups (42.3±11.6 vs 72.3±9.6,73.3±9.2,P<0.01).Conclusions The method that Rheum officinale Combines captopril is more effective to lower UAER in aged NIDDM patients with microalbuminuria.