1-(反式-4-丙基环己基)-2-[4-(3'-氟-4'-对烷基苯基)-联苯]丙烷类液晶的合成

Synthesis of Liquid Crystal 1-(trans-4-Propylcyclohexyl)-2-[4-(3'-fluoro-4'-p-alkylphenyl)-diphenyl]Propane

以3-氟溴苯，对溴苯腈等为原料，经过格氏反应，Suzuki反应，Witting反应，氢化反应等共7步反应最终合成3种标题化合物类液晶化合物，总收率约为25％-35％，产物气相色谱纯度均〉99．5％，结构经IR、^1HNMR及GC-MS确证。其中1-（反式14-丙基环己基）-2-[4-（3’-氟苯基）-苯基]丙烷与正丁基锂物质的量比为1：1．3，锂化时间为2h。

Three kinds of 1 - （ trans-4 -propylcyclohexyl ） -2- [ 4 - （ 3＇-fluoro-4＇-p-alkylphenyl ） -diphenyl ] propane liquid crys- tals were synthesized from 1-bromo-3-fluorobenzene,4-brumo- benzonitrile etc. as raw materials by a total of seven step reac- tions such as Grignard reaction, Suzuki reaction,Witting reac- tion, hydrogenation reaction etc. The overall yield was about 25% ~ 35% with purity above 99.5% （GC）. Structures of the compounds were confirmed by IR, I HNMR and GC-MS. The mole ratio of the 1 - （ trans-4 -propylcyclohexyl ） -2 - [ 4 - （ 3＇- fluorophenyl）-phenyl] propane with butyl lithium was I： 1.3 and the reaction time of lithiation reaction was 2 h.