摘要
慢性B淋巴细胞增殖性疾病根据免疫表型可分为不同亚型,免疫表型在各亚型的诊断及鉴别诊断中发挥着重要作用,典型(慢性)B淋巴细胞白血病免疫表型为CD5+、CD23+、FMC(flinders medical centre)7+;而毛细胞白血病特异性高表达CD22、CD25、CD103和CD11c;滤泡性淋巴瘤主要表达CD20、CD10、CD22、CD79a,不表达CD5;套细胞淋巴瘤则过度表达CD5+、FMC7+、Bcl-2+、细胞周期蛋白(cyclinD1+);典型瓦氏巨球蛋白血症不表达CD5及CD23,而变异型则表达;边缘区B细胞淋巴瘤的典型免疫表型为CD5-、CD10-、CD23-、cyclinD1-。对于不典型的慢性B淋巴细胞增殖性疾病需结合病理学、遗传学、分子生物学诊断,从而指导临床治疗及预后。
Based on the immunophenotype,chronic B lymphocyte proliferation disease can be categorized into different isoforms.Immunophenotype plays an important role in diagnosis and differential diagnosis of all subtypes.The typical （chronic） immunophenotype of B-CLL are CD5 ＋,CD23＋,FMC-7 ＋.HCL specifically expresses CD22,CD25,CD103 and CD11c.FL mainly expresses CD20,CD10,CD22 and CD79a,but it doesn＇t express CD5.MCL over-expresses CD5＋,FMC7 ＋,Bcl-2 ＋ and cyclinD1 ＋.Typical WM doesn＇t express CD5 and CD23,but the variant does.The typical immunophenotype of MZL are CD5-,CD10-,CD23-and cyclinD1-.As for variants of BclPD,pathology,genetics,molecular biology should be correlated for diagnosis,so as to guide the clinical treatment and prognosis.
出处
《医学综述》
2014年第6期997-1000,共4页
Medical Recapitulate
