肿瘤基因治疗的病毒载体研究进展

Research Progress in Viral Vectors of Cancer Gene Therapy

肿瘤基因治疗是通过载体将遗传物质转移入宿主细胞,使肿瘤细胞凋亡,包括原发瘤和转移瘤。目前,应用于肿瘤基因治疗的载体分为病毒载体和非病毒载体,病毒载体的转移效率高,其中腺病毒载体、腺病毒相关病毒载体、反转录病毒载体和疱疹病毒载体等已广泛应用于基础研究和临床试验。

Cancer gene therapy is the transfer of genetic material to the cells of host with the goal of eradicating cancer cells, both in the primary tumor and metastases. Therapeutic agents in cancer gene therapy are delivered to the tumor cell using a carrier that might be either a nonviral vector or,the more efficient at gene delivery to target cells, a viral vector. It contains adenoviral vectors, adeno-associated virus vectors, retro- viral vectors and herpes viral vectors, which have been widely used in basic research and clinical trials.