胎儿严重先天性心脏病与NT增厚的相关性研究进展

Study on the Correlation between Severe Fetal Congenital Heart Disease with NT Thickening

胎儿颈项透明层（NT）增厚既往仅作为胎儿染色体异常的一个重要筛查指标.在其后的研究中不断有学者发现,NT增厚的胎儿发生先天性心脏病的概率较NT值正常的胎儿明显增高.使用阴道超声检查,在二维灰阶超声基础上配合彩色多普勒检查,完全能够在早孕晚期（孕11～13周＋6 d）对NT增厚的目标胎儿进行早期超声心动图检查,对于未在早孕期发现心脏结构严重异常的目标胎儿也能够为其后的心脏专项检查提供依据.

Fetal nuchal translucency（NT） thickness was previously only used as an important screening index of fetal chromosomal abnormalities. In the subsequent study investigators have found：the fetal congenital heart disease incidence of fetus with NT thickening is significantly higher than the fetus with normal NT value. The use of transvaginal ultrasound with color Doppler on the basis on two-dimensional gray ultrasound can realize the early echocardiography of target fetuses with NT thickening at the late stage of early pregnancy （11-13 weeks ＋6 days） to early late. For object without serious abnormal fetal heart structure found in early preg- nancy,the basis for the special insoection of the heart can also be nmvided for the later cardiac examination.