头孢曲松钠相关性胆囊结石的机制研究进展

Research Progress of Mechanisms of Ceftriaxone Sodium Associated Gallstones

头孢曲松钠是第三代头孢菌素类抗生素,因其抗菌谱广、半衰期长而广泛地应用于严重感染性疾病。但在其临床应用的过程中,头孢曲松钠引发胆囊结石的报道越来越多,逐渐引起了临床医师的重视,但目前对其成石的机制尚未完全了解。该文通过对头孢曲松钠的血药浓度、用药疗程、胆汁的淤积、胆囊的收缩功能以及在用药过程中病情的具体情况(如禁食、脱水及手术操作等)等方面的研究,对头孢曲松钠相关性胆囊结石的成石机制进行了综述。

Cefiriaxone sodium is the third generation of cephalosporins, because of its extensive antimi- crobial spectrum and a long plasma half-life,ceftriaxonc is used commonly in patients with serious bacterial infections. Along with the clinical application of ceftriaxone, more and more articles about ceftriaxone associ- ated gallstones were reported, drawing more attentions from the clinicians, but at present, the mechanisms of the stone frorming have not been fully understood yet. Here mainly reviews the mechanisms of ceftriaxone sodium associated gallstones from the aspects of the concentration of ceftriaxone sodium, treatment duration, the deposition of bile, gallbladder contraction function and the specific disease circumstances in the process of treatment （such as fasting, dehydration and operation aspects, etc. ）.