两种方法治疗不明原因复发性流产的临床比较分析

Clinical Comparative Analysis of Two Treatments for Unexplained Recurrent Abortion

目的比较淋巴细胞主动免疫治疗和传统安胎治疗对不明原因复发性流产(URSA)患者的治疗效果。方法选择2010年6月至2011年6月在海口市琼山区府城医院就诊的URSA患者110例采用丈夫外周血淋巴细胞主动免疫治疗作为免疫治疗组;另外选取同期收治的60例因各种因素不同意采取主动免疫治疗的URSA患者采用传统的安胎治疗作为传统安胎组。两组均治疗至孕12周。比较两组的妊娠成功率及妊娠成功者的最终妊娠结局。结果免疫治疗组妊娠成功率为71.8%,传统安胎组妊娠成功率为30%,免疫治疗组妊娠成功显著高于传统安胎组(P<0.05)。两组妊娠成功患者足月分娩、早产、>20周流产、胎儿生长受限、妊娠期高血压、妊娠期糖尿病的发生率比较,差异均无统计学意义(P>0.05)。结论淋巴细胞主动免疫治疗对URSA的疗效显著,优于传统安胎治疗,值得临床推广。

Objective To compare the efficacy of active immunotherapy with lymphocytes and traditional medical treatment in treating unexplained recurrent spontaneous abortion（URSA）.Methods From Jun.2010 to Jun.2011 in Haikou City Qiongshan District Fucheng Hospital 110 URSA patients were selected as immunotherapy group,and they were given the husband＇s peripheral blood lymphocytes for active immunotherapy;another 60 URSA patients over the same period due to various factors who did not agree to take the active immunotherapy were included as traditional tocolysis group,and given the traditional tocolysis treatment.Both groups were treated to 12 weeks pregnancy.Pregnancy success rates and the final outcome of successful pregnancy of the two groups were compared.Results Successful pregnancy rate of the immunotherapy group was 71.8%,of the traditional tocolysis group was 30%,the difference was statistically significant（P 〈 0.05）.The successful full-term pregnancy,preterm delivery,〉 20 weeks miscarriage,fetal growth restriction,gestational hypertension,gestational diabetes incidence of the two groups were not statistically significantly different （P 〉 0.05）.Conclusion Active immunotherapy is an effective treatment for URSA,which is better than traditional tocolysis,thus is worthy of promotion in clinical.