钯催化官能化芳基膦酸二乙酯的合成研究

Synthesis of Functionalized Aryl Phosphonates by Pd Catalyzed Cross-coupling of Aryl Halides with Diethyl Phosphite

通过对催化剂、配体、碱、溶剂的优化筛选,以官能化卤代芳烃与亚磷酸二乙酯为反应原料,以无水乙醇为溶剂,Pd(OAc)2为催化剂,PPh3为配体,Et3N为碱,在80℃下反应24 h,以60%左右的收率合成得到了系列芳基膦酸二烷基酯衍生物,其结构经FT-IR,1H NMR和13C NMR表征。

The palladium catalyzed arylation of diethyl phosphite with functionalized aryl halides was examined. With Pd（OAc）2（2%,n/n） as the catalyst, PPh3（6%,n/n）as the ligand, and Et3N as the base, the reaction was carried out in ethanol at 80℃ for 24 hours, affording the corresponding diethyl aryl phosphonates in moderate yields. The product structures were characterized by FT-IR, 1H NMR and 13C NMR spectra.