生存素在肿瘤中的作用及其耐药机制

Roles and resistance mechanisms of survivin in tumor

肿瘤治疗中的耐药问题是影响疾病转归的重要因素,目前已有大量研究发现,生存素（survivin）具有抑制肿瘤细胞凋亡、调控肿瘤细胞周期、促进血管生成、促进肿瘤转移的作用,并可与多种基因及蛋白相互作用,影响肿瘤细胞耐药性.

Drug resistance in tumor treatment is an important factor that affects disease outcome. A lot of researches show that survivin can inhibit tumor cell apoptosis, regulate cell cycle, promote angiogenesis and tumor metastasis. The interactions among survivin, genes and proteins can influence the drug resistance of tumor cells.