MMP-2和MMP-9水平与急性冠脉综合征的相关性临床研究

The clinical study on the correlation between MMP-2 and MMP-9 levels and acute coronary syndrome

目的分析基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)在急性冠脉综合征(ACS)中的水平变化及对临床意义。方法随机选取2011年6月至2013年5月期间收治的急性冠脉综合征患者76例作为观察对象,同时选取70例正常人与66例稳定稳定型冠心病患者作为对照,酶联免疫吸附分析法检测血清MMP-2、MMP-9水平,比较MMP-2和MMP-9水平差异性。结果 ACS患者MMP-2为(204.68±38.42)ng/ml,MMP-9为(781.62±287.37)ng/ml,显著高于稳定型冠心病和正常人群(P<0.05),其中急性心肌梗死(AMI)患者MMP-2为(276.82±53.86)ng/ml,MMP-9为(793.56±264.38)ng/ml,显著高于不稳定型心绞痛(UA)患者(P<0.05)。结论 ACS患者MMP-2和MMP-9呈高表达,MMP-2和MMP-9与急性冠脉综合征关系密切,有望成为预测急性冠脉综合征病情的血清学指标,值得临床深入研究。

Objective To analyze the levels and its clinical significance of MMP - 2 （ matrix metalloproteinase - 2 ） and MMP - 9 （ matrix metalloproteinase 9） for acute coronary syndrome （ACS）. Methods From June, 2011 to May, 2013, 76 patients with acute coronary syndrome were selected as the observation objects in our hospital. We also selected 70 normal people and 66 cases of stable coronary artery disease as the control group. The enzyme - linked immunosorbent assay was used to detect the levels of serum MMP - 2 and MMP - 9. The different levels of MMP - 2 and MMP - 9 were compared. Results MMP - 2 of ACS patients was （204.68 ± 38.42） ng/ml, MMP - 9 was （781.62 ± 287.37） ng/ml. They were significantly higher than stable coronary artery disease and normal people （ P 〈0.05 ）. MMP - 2 of AMI patients was （276.82 ± 53.86） ng/ml, MMP - 9 was （793.56± 264.38） ng/ml. They were significantly higher than UA patients （ P 〈 0.05 ）. Conclusion Expression of MMP -2 and MMP -9 were higher in the patients with ACS. There was a close relationship between MMP -2 and MMP -9 and the patients with acute coronary syndrome. It was expected to become the prediction of serum markers for acute coronary syndrome. A deeper clinical research was needed.