盐酸纳洛酮治疗急性颅脑损伤患者的临床疗效观察

Observation of Clinical Efficacy of Naloxone Hydrochloride for the Treatment of Patients with Acute Brain Injury

【目的】探讨盐酸纳洛酮治疗急性颅脑损伤患者的临床疗效。【方法】选择本院2013年1月至2013年10月收治的50例急性颅脑损伤患者的临床资料，其中，观察组25例患者采用盐酸纳洛酮进行治疗，而对照组25例患者采用常规治疗措施，比较两组患者的临床疗效。【结果】治疗后，观察组患者的总有效率为92．00％，明显高于对照组患者，组间差异具有明显统计学意义（ P ＜0．05），治疗15 d后，观察组患者的颅内压较对照组明显下降，组间差异具有明显统计学意义（ P＜0．05），治疗6 d、8 d、11 d、15 d后，观察组患者的GCS评分均较对照组明显改善，组间差异均具有明显统计学意义（ P ＜0．05）。【结论】早期应用纳洛酮治疗急性颅脑损伤患者具有十分显著的效果，大大降低了伤残率和病死率，有利于患者的预后恢复，值得临床应用。

[Objective] To explore the clinical efficacy of naloxone hydrochloride for the treatment of pa-tients with acute brain injury .[Methods] Clinical data of 50 patients with acute brain injury in our hospital from Jan .2013 to Oct .2013 were collected .The observation group（ n=25） was treated with naloxone hydro-chloride ,while the control group（ n=25） was treated with conventional treatment .Clinical efficacy was com-pared between two groups .[Results]After treatment ,the total effective rate in the observation group was 92 . 00% which was obviously higher than that in the control group ,and there was significant difference between two groups（ P〈0 .05） .Compared with the control group ,intracranial pressure in the observation group 15d after treatment was obviously decreased ,and there was significant difference between two groups （ P〈0 .05） . Compared with the control group ,GCS score in the observation group 6d ,8d ,11d and 15d after treatment was improved obviously ,and there was significant difference between two groups （ P〈0 .05） .[Conclusion] Early use of naloxone for the treatment of patients with acute brain injury has a very significant efficacy ,and greatly reduces the disability and mortality ,and is helpful to restore the prognosis of patients .Therefore it is worthy of clinical application .