吡拉西坦氯化钠注射液治疗脑出血的临床疗效分析

Analysis of Clinical Efficacy of Piracetam Sodium Chloride Injection in the Treatment of Cerebral Hemor-rhage

【目的】探讨应用吡拉西坦氯化钠注射液治疗脑出血患者的临床效果。【方法】选择本院2010年8月至2012年8月间进行诊治的120例脑出血患者，将其随机分为两组，试验组的60例患者应用20％吡拉西坦氯化钠注射液进行治疗，每次滴注100mL快速输入，每6～8h一次，连续应用7d ；7d后运用常规滴注速度滴注7d。对照组60例患者，快速静脉滴注20％甘露醇125mL ，每6～8h一次，连续应用7d；所有患者均连续进行颅内压监护，并在治疗前、治疗后的d7及d14分别观察比较两组患者颅内压，血浆神经肽Y及神经功能缺损评分的改变情况。【结果】试验组与对照组患者治疗前颅内压两组相比较差异无显著性（P＞0．05），经过药物治疗后，两组患者的颅内压较治疗前均明显降低，且治疗前后相比较差异有显著性（P＜0．05）。但两组之间颅内压及降低幅度相比较差异均无显著性（P＞0．05）。试验组与对照组患者治疗前两组神经功能缺损评分，神经肽相比较差异均无显著性（P＞0．05），治疗后14d两组神经功能缺损评分，神经肽较治疗前明显下降，且治疗前后相比较差异均有显著性（P＜0．05）。试验组比对照组下降更明显，且两组之间相比较差异均有显著性（P ＜0．05）。【结论】脑出血患者运用吡拉西坦氯化钠注射液进行治疗可明显降低颅内压，改善患者的神经功能缺损评分，显著降低血浆神经肽Y水平。

[Objective] To explore the clinical efficacy of piracetam sodium chloride injection in the treatment of pa-tients with cerebral hemorrhage .[Methods] Totally 120 patients with cerebral hemorrhage in our hospital from Aug . 2010 to Aug .2012 were chosen and randomly divided into two groups .The experiment group（ n=60） was treated with 20% piracetam sodium chloride injection 100ml by fast infusion every 6~8h for continuous 7d ,and then instilled by rou-tine velocity for 7d after 7d .The control group（ n=60） was treated with intravenous injection of 20% mannitol 125ml every 6~8h for continuous 7d .All patients received consecutive monitoring of intracranial pressure .The changes of in-tracranial pressure ,plasma neuropeptide Y and neural function deficit score before ,7d and 14d after treatment were ob-served .[Results] There was no significant difference in intracranial pressure before treatment between experiment group and control group（ P〉0 .05） .Compared with before treatment ,intracranial pressure in two groups after drug therapy were obviously decreased ,and there was significant difference between before and after treatment （ P〈0 .05） .There was no significant difference in intracranial pressure and the decreasing level between two groups （ P 〈0 .05） .There was no significant difference in neural function deficit score and neuropeptide before treatment between experiment group and con-trol group（ P〉0 .05） .Compared with before treatment ,neural function deficit score and neuropeptide in two group were obviously decreased ,and there was significant difference between before and after treatment （ P〈0 .05） .Neural function deficit score and neuropeptide in experiment group were decreased more obviously than that in control group ,and there was significant difference （ P〈0 .05） .[Conclusion]Piracetam sodium chloride injection for the treatment of patients with cerebral hemorrhage can obviously reduce intracranial pressure ,improve the nerve function deficit score and markedly de-crease plasma level of neuropeptide .