SPECT脑血流灌注显像应用于多发性硬化患者认知功能障碍的临床研究

Clinical Study of SPECT Perfusion Imaging in Multiple Sclerosis Patients with Cognitive Dysfunction

目的探讨SPECT脑血流灌注显像应用于多发性硬化(MS)患者认知功能障碍的临床效果。方法入选我院2010年1月至2013年1月收治的MS患者30例作为观察对象,根据CT、MRI等影像学检查分为脊髓型14例和脑/脑脊髓型16例,与同期15例健康体检人群进行对比,分析MS认知功能障碍患者的脑血流改变。结果脑/脑脊髓型MS组和脊髓型MS组认知障碍发生率62.5%(10/16)和42.9%(6/14),均显著高于对照组6.7%(1/15),MS病例组在多处放射性比值低于对照组,以右丘脑和左顶叶更明显,差异均具有统计学意义(均P<0.05)。结论 SPECT脑血流灌注显像可早期诊断MS患者认知功能障碍。

Objective To explore the SPECT perfusion imaging in multiple sclerosis （MS） patients with cognitive dysfunction. Methods Thirty 30 MS patients in our hospital from January 2010 to January 2013 were selected as the research objects in this study. All cases were divided into spinal cord group （14 cases） and brain / myelencephalon group （16 cases） according to CT and MRI examination. 15 healthy physical examination people at the same period were selected as the control group to analyze the change of cerebral blood flow of MS patients with cognitive dysfunction. Results The incidence of cognitive dysfunction was 62.5% （10/16） and 42.9% （6/14） in brain / myelencephalon group and spinal cord group respectively, both were significantly higher than 6.7% （1/15） of the control group; Many of radioactivity ratios in patients with MS were lower than those in the control group, most obviously in right thalamus and left parietal; All P 〈0.05. Conclusions SPECT cerebral perfusion imaging can early diagnose cognitive dysfunction in MS patients.