硝酸甘油与硫酸镁对妊娠子痫前期合并心衰的临床效果比较分析

Comparative Analysis on the Clinical Effect of Nitroglycerin and Magnesium Sulfate for the Treatment of Pre-Eclampsia Associated with Heart Failure

目的观察并探讨妊娠子痫前期合并心衰患者的预防措施与临床治疗要点。方法取80例妊娠子痫前期合并心衰患者为研究对象,随即将其均分为对照组与实验组各40例,给予对照组硫酸镁静注治疗,实验组则行硝酸甘油静脉微量泵入治疗,观察用药前后两组心率和血压、血细胞压积差异。结果与对照组相比,实验组在用药前后的平均心率与血压均有显著下降,组间差异显著,具有统计学意义(P<0.05)。结论在预防心衰的各项措施中,产前定期检查、迅速控制血压以及重视诱因是关键所在;而对于子痫前期且伴有心衰合并症患者而言,硝酸甘油效果确切,安全性较高,能够有效控制围产期围生儿和孕产妇死亡率,值得临床推广使用。

Objective To observe and discuss the preventive measures and clinical treatment point of patients with pre-eclampsia associated with heart failure. Methods Eighty patients with pre-eclampsia associated with heart failure were selected in this study and divided into two groups, with 40 cases in each group. Patients in the control group were treated with magnesium sulfate by intravenous, while patients in experimental group were treated with nitroglycerin for intravenous micro-pump. The heart rate, blood pressure, and hematocrit before and after therapy were observed and compared between two groups. Results Compared with the control group, the experimental group were significantly decreased in average heart rate and blood pressure before and after treatment, there was statistical significance （P〈0.05）. Conclusions Regular prenatal inspection, rapid control of blood pressure and emphasis on incentives are the keys to prevent heart failure. For patients with pre-eclampsia associated with heart failure, nitroglycerin has exact effect and high security; it can effectively control the mortality of perinatal child and puerpera.