血清降钙素原在慢性阻塞性肺疾病急性加重期患者的表达水平及其临床意义

Expression Level and Its Clinical Significance of Serum Procalcitonin in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

目的探讨血清降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的表达水平及其临床意义。方法入选我院2010年10月至2012年10月的AECOPD患者50例,根据用药依据不同分为两组各25例,对照组根据患者情况由临床医师经验性使用抗生素,观察组根据PCT水平使用抗生素。观察两组患者PCT水平的变化,治疗有效率和抗生素的使用情况。结果观察组临床有效率88.0%(22/25)高于对照组80.0%(20/25),但组间差异无统计学意义(P>0.05);治疗4 d、7 d和10 d时,观察组PCT表达均显著低于对照组,抗生素的使用时间和产生的医疗费用均显著低于对照组,差异均具有统计学意义(均P<0.05)。结论 AECOPD患者的PCT表达明显升高,且监测PCT可以指导临床使用抗生素。

Objective To explore the expression level and its clinical significance of serum procalcitonin （PCT） in acute exacerbation of chronic obstructive pulmonary disease （AECOPD） patients. Methods Fifty patients with AECOPD in our hospital from October 2010 to October 2012 were selected in this study and divided into two groups according prescription basis, with 25 cases in each group. Patients in control group treated with antibiotics based on the experience of clinicians, while patients in observation group were treated with antibiotics based on PCT level. The change of PCT level, treatment effective rate and use condition of antibiotics of two groups were observed. Results The clinical efficiency was 88.0% in observation group, higher than 80.0% in control group, but the difference was not statistically significant ：（_P 〉0.05）. At 4 d, 7 d, and 10 d of treatment, the PCT levels of observation group were significantly lower than those of control group correspondingly （P 〈0.05）. The use time and medical expenses of observation group were significantly lower than those of control group （P 〈0.05）. Conclusions The PCT expression is significantly increased in patients with AECOPD. Monitoring PCT can guide the clinical use of antibiotics.