p120连环素与上皮性钙粘附蛋白在基底细胞样乳腺癌中表达的临床意义

Expressions of p120 Catenin and E-Cadherin and Their Clinical Significance in Basal-Like Breast Cancer

目的探讨p120连环素(p120)与上皮性钙粘附蛋白(E-cad)在基底细胞样乳腺癌(BLBC)中表达的临床意义。方法采用免疫组织化学法,观察p120、E-cad在56例BLBC患者中的表达与发病年龄、肿瘤大小、组织学分级、淋巴结转移和pTNM分期的关系以及p120和E-cad表达的相关性。结果①p120在年龄分组中表达差异无统计学意义;在肿瘤大小分组、组织学分级分组、淋巴结转移分组、pTNM分期分组中表达差异均有统计学意义。②E-cad在年龄分组、肿瘤大小分组中表达差异均无统计学意义;在组织学分级分组、淋巴结转移分组、pTNM分期分组中表达差异均有统计学意义。③在BLBC中p120异常表达与E-cad表达减弱/消失的相关性有统计学意义。结论在BLBC中,p120异常表达与E-cad表达减弱/消失均提示预后不良,两者的表达有正相关性。

Objective To investigate the expressions and significance of p120 catenin and E-cadherin （E-cad） in basal-like breast cancer （BLBC）. Methods Immunohistochemical method was performed to determine the relationship between expressions ofpl20 catenin, E-cad in 56 cases of basal-like breast cancer and their clinicopathological characteristics. Results （2）p 120 expression was not statistically significantly different in different ages. The different expression of p120 was significantly associated with tumor size, histological grade, lymph node status and pTNM stage. （~）E-cad expression was not statistically significantly different in different ages and tumor sizes. The different expression of E-cad was significantly associated with histological grade, lymph node status and pTNM stage. （~ The aberrant expression of p120 and the attenuated/absent expression of E-cad were correlated in basal-like breast cancer, with statistical significance. Conclusions The aberrant expression of p120 and the attenuated/absent expression of E-cad are positively correlated, probably indicating unfavorable prognosis in basal-like breast cancer.