综合疗法治疗慢性阻塞性肺疾病临床观察

Clinical observation of comprehensive treatment on chronic obstructive pulmonary disease

目的探讨抗生素、解痉平喘、雾化及激素的综合治疗法治疗慢性阻塞性肺疾病的临床可行性。方法选取2012年6月-2013年6月来该院接受治疗慢性阻塞性肺疾病的患者274例,随机分为试验组与对照组各137例。对照组采用常规支气管扩张剂、抗生素,部分利用呼吸兴奋剂、强心利尿以及激素治疗,通过氧疗的配合,维持患者体内电解质、酸碱以及水的平衡等进行相应治疗。试验组采用抗生素、解痉平喘、雾化及激素的综合法进行治疗。观察治疗前后2组血气分析改善情况和临床疗效。结果 2组治疗后PaCO2、SpO2和PaO2较治疗前均有明显改善,但试验组改善情况优于对照组,试验组总有效率为84.67%显著高于对照组62.77%,差异有统计学意义(P<0.05)。结论采用抗生素、解痉平喘、雾化及激素的综合治疗法治疗慢性阻塞性肺疾病安全性高、临床效果明显,具有临床应用的价值。

Objective To explore the clinical feasibility of comprehensive treatment on chronic obstructive pulmonary disease, including Antibiotics, antispasmodic, atomization and hormone. Methods 274 cases of patients with chronic obstruc- tive pulmonary disease （COPD） in June 2012 to June 2012 were randomly divided into experimental group and control group, 137 cases in each. The control group were treated with conventional bronchodilator, antibiotics, and some use of respiratory stimulants, strong heart,diuresis and hormone therapy, maintaining the balance of patient electrolyte, acid and alkali, water and so on combined with oxygen therapy. The experimental group patients were treated with comprehensive treatment including Antibiotics, antispasmodic, atomization and hormone. The blood gas analysis and clinical curative effect of 2 groups were ob- served. Results After treatment, the results of blood analysis such as PaCO2 , SpO2 and PaO2 were better than before the treat- ment, and the experimental group was better than control group;The total effect rate of the experimental group was 84.67%, which was higher than 62.77% of the control group,~d the differences were statistically significant （P 〈 0.05 ）. Conclusion Comprehensive therapy with antibiotics, antispasmodic, atomization and hormone has high safety in patients with COPD, the clinical effect of which is obvious, and has the value of clinical application.