甘精胰岛素和格列美脲对初诊2型糖尿病的疗效对比研究

Clinical Effect Comparison of Glargine and Glimepiride in the Treatment of Type 2 Diabetes Mellitus

目的对比甘精胰岛素与格列美脲治疗初诊2型糖尿病患者的临床疗效。方法选取2011年1月—2012年1月我院收治的68例2型糖尿病患者,将患者按照使用治疗药物的不同分为观察组和治疗组。观察组采用甘精胰岛素联合二甲双胍治疗;对照组采用格列美脲联合联合二甲双胍治疗。比较两组患者治疗前后的B细胞功能情况、血糖控制情况、低血糖和体质指数情况。结果治疗后两组患者的FPG、2hPG、HbA1c均较治疗前降低,差异有统计学意义(P<0.01);两组患者胰岛素分泌指数(HOMA-β)和胰岛素抵抗指数(HOMA-IR)差值比较,差异无统计学意义(P>0.05)。观察组达标时间较对照组达标时间短,差异有统计学意义(P<0.05)。结论甘精胰岛素与格列美脲均能够对初诊2型糖尿病患者起到良好的治疗效果,但是甘精胰岛素在降糖方面更加迅速、客观。

Objective To study the clinical effect of glargine and glimepiride in the treatment of type 2 Diabetes mellitus.Methods A total of 68 patients with type 2 diabetes mellitus from Jan.2011 to Jan.2012 in our hospital were divided into observation group and treatment group.The observation group was treated with glargine and metformin,the treatment group was treated with glargine and glimepiride.The condition of B cell,controlling of blood glucose,hypoglycemia and BMI were compared.Results After treatment,the FPG,2hPG,HbA1c of all the patients were lower than before,the difference was statistically significant（P＜0.01）;To compare the HOMA-β and HOMA-IR of two groups,the difference was not statistically significant（P＞ 0.05）.The standard time of observation group was shorted than the control groups,the difference was statistically significant（P＜0.05）.Conclusion Glargine and glimepiride are able to play a newly diagnosed type 2 diabetic mellitus patients with good therapeutic effect,but more rapid glargine objective in terms of hypoglycemic.