盐酸纳洛酮联合醒脑静治疗捂热综合征的疗效评价

Effect of Naloxone Hydrochloride Combined with Xingnaojing in the Treatment of Infant Muggy Syndrome

目的探讨盐酸纳洛酮联合醒脑静治疗捂热综合征的疗效及安全性。方法选取2011—2013年在广东省广州市妇女儿童医疗中心接受治疗的150例捂热综合征患儿,随机分为观察组与对照组,各75例。对照组采取综合治疗,观察组在对照组的基础上再加用盐酸纳洛酮和醒脑静。观察两组患儿的疗效。结果治疗后,观察组75例全部治愈,对照组75例中,1例死亡,1例未治愈自行出院;两组比较差异有统计学意义(P<0.05)。观察组呼吸平稳时间、血液恢复正常时间、恢复时间、肌张力恢复时间和平均住院时间均少于对照组,差异有统计学意义(P<0.05)。观察组患儿均无后遗症,对照组中智力下降3例,呆傻2例,癫痫2例,聋哑1例。两组后遗症比较差异有统计学意义(P<0.01)。结论盐酸纳洛酮注射液联合醒脑静注射液治疗捂热综合征疗效显著。

Objective To evaluate the efficacy and safety of Naloxone hydrochloride combined with Xingnaojing in the treatment of infant muggy syndrome.Methods To select 2011-2013 in Guangzhou City,Guangdong Province Women and Children Medical Center for treatment of 150 cases muggy syndrome were randomly divided into observation group and control group with 75 cases.The control group took comprehensive treatment,the observation group in the control group treated with the Naloxone hydrochloride injection and Xingnaojing injection.To observe the two groups of children.Results After treatment,75 cases of the observation group were cured,the control group,one patient died,one case did not heal on their own hospital;The difference was statistically significant（P＜0.05）.Observation group stationary time breathing,the blood returns to normal time,recovery time,recovery time and muscle tone average hospitalization time were less than the control group,the difference was statistically significant（P＜0.05）.Observation group of children with no after-effects,in the control group,three cases of mental decline,two cases of Daisha,two cases of epilepsy,one case of the deaf.Difference between the two groups was statistically significant sequelae（P＜0.01）.Conclusion Naloxone hydrochloride injection combined syndrome XNJI muggy significant.