妊娠合并甲状腺功能亢进症110例临床分析

The clinical analysis of hyperthyroidism in pregnancy: on 110 cases

目的分析妊娠合并甲状腺功能亢进的治疗对妊娠结局的影响。方法将妊娠合并甲状腺功能亢进症孕妇105例分为治疗组68例和对照组37例。治疗组为妊娠期经过系统治疗且分娩前甲状腺功能基本正常者,对照组为未经正规系统的治疗或曾进行短暂治疗后自行停药在住院分娩前发现甲状腺功能显著升高者。比较2组孕妇甲状腺功能及妊娠结局。结果治疗组FT3、FT4水平明显低于对照组,TSH明显高于对照组;治疗组低体重儿(LBW)、早产、新生儿窒息、新生儿甲亢、新生儿甲减及新生儿黄疸的发生率均低于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论妊娠合并甲亢需引起临床医师重视,加强孕妇甲状腺功能监测,积极治疗可减少孕妇和胎儿不良事件的发生。

Objective To analysis the 110 cases of hyperthyroidism in pregnancy. Methods 105 cases patients with hyperthyroidism in pregnancy were randomly divided into treatment group （68cases）and control group（37cases）. Treatment group was treated by systemic therapy and the thyroid function was normal. Control group was founded thyroid function was sig- nificantly higher. Compared the thyroid function and pregnancy outcomes of 2 groups. Results The level of F33 and FT4 of treatment group were lower than that of control group, the level of TSH of treatment group was higher than that of control group, the incidence of low birth weight children, preterm, asphyxia, neonatal hyperthyroidism, neonatal hypothyroidism, neonatal jaun- dice were lower than that of control group, the difference was statistically significant （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Hy- perthyroidism in pregnancy should cause the attention of physician. Strengthen the monitored of ihyroid function in pregnant woman, aggressive treatment can reduce the occurrence of adverse events.