碳水化合物的组合合成(英文)

Combinatorial Synthesis of Carbohydrates

碳水化合物的组合合成是一项新兴技术 ,该技术可以在短时间内合成大量用于进行生物活性筛选的寡糖及拟糖物。液相与固相合成技术可以极大地加快药物研究与开发进程。作者针对该技术在碳水化合物合成方面的研究进展情况进行讨论。

Combinatorial synthesis of carbohydrates is the newly formed technique to synthesize and biologically screen large set of oligosaccharides and glycomimetics in a very short time. Solution phase and solid phase methodology have been used in this technique to tremendously accelerate drug development process. In this paper, current approaches regarding carbohydrate synthesis in this field will be discussed.